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Literature summary extracted from

  • Fujikawa, K.; Davie, E.W.
    Human factor XII (Hageman factor) (1981), Methods Enzymol., 80, 198-211.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.38 10000
-
 the human enzyme is a mixture of two forms, one form is composed of two chains, x * 28000 + x * 52000, a second enzyme form, x * 10000 + x * 28000 + x * 40000 Homo sapiens
3.4.21.38 28000
-
 the human enzyme is a mixture of two forms, one form is composed of two chains, x * 28000 + x * 52000, a second enzyme form, x * 10000 + x * 28000 + x * 40000 Homo sapiens
3.4.21.38 40000
-
 the human enzyme is a mixture of two forms, one form is composed of two chains, x * 28000 + x * 52000, a second enzyme form, x * 10000 + x * 28000 + x * 40000 Homo sapiens
3.4.21.38 52000
-
 the human enzyme is a mixture of two forms, one form is composed of two chains, x * 28000 + x * 52000, a second enzyme form, x * 10000 + x * 28000 + x * 40000 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.38 proteolytic modification activation of the factor XII by proteolysis takes place in the presence of negatively charged materials. It is catalyzed by plasma enzymes, such as kallikrein, factor XIa and plasmin. Plasma kallikrein is probably the major activator under physiological conditions. High molecular weight kininogen stimulates the activation severalfold Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.38
-
 Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.38 additional information
-
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
3.4.21.38 -20°C, stable for at least several months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 D-Pro-Phe-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.38 ? the human enzyme is a mixture of two forms, one form is composed of two chains, x * 28000 + x * 52000, a second enzyme form, x * 10000 + x * 28000 + x * 40000 Homo sapiens